There is evidence for increased oxidative stress & inflammation in Chronic Fatigue Syndrome
Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants.
According to Morris & Maes (2014) sources of continuous activation of O&NS and immune inflammatory pathways in CFS are:
chronic, intermittent and opportunistic infections, bacterial translocation (aka leaky gut), autoimmune responses, mitochondrial dysfunctions, activation of the Toll-Like Receptor Radical Cycle, and decreased antioxidant levels
These have all ben discussed elsewhere in the learning zone. An article on digestive health can be found here (which discusses leaky gut and TLR Radical Cycle), and an article on mitochondrial dysfunction can be found here, which discusses a key antioxidant called Glutathione.
Oxidative Stress & Inflammation In Chronic Fatigue Syndrome: Conclusion
The above causes of oxidative stress and inflammation explains why we frequently run stool, breath and leaky gut testing in our clients.
Chronic Fatigue Syndrome is often preceded by a stressor, such as from an accident or from surgery, psychological stress, viral, parasitic or bacterial infections, episodes of strenuous physical activity, etc. Often however the infections are secondary to a compromised immune system. Perhaps the infection is the final nail in the coffin rather than the sole trigger of the condition?
Meeus et al. (2013) The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?
Myhill et al. (2013) Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) – a clinical audit, Int J Clin Exp Med; 6(1):1-15
Morris & Maes (2014) Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS), Current Neuropharmacology; 12, 168-185